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It can increase the chance of false positives or real elevations in tumor markers, such as: Carcinoembryonic antigen (CEA) CYFRA 21-1 Neuron-specific enolase (NSE) When this happens, it can lead to over-testing or early cancer screening

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Genetic testing can detect a gene mutation in about of families with signs of HHT, which if found can establish the diagnosis of HHT in individuals and families who are unsure about whether they have HHT