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Long-term management strategies include quitting smoking, medications for inflammation reduction and mucus thinning, pulmonary rehabilitation, and supportive care like oxygen therapy

I quit smoking the day I found out I was pregnant, which was nine years ago

For instance, Tungtrongchitr et al

The downregulation of PRKN in lung epithelial cells of COPD patients may contribute to the deficiency in mitophagy observed in these patients, leading to the accumulation of aberrant mitochondria and increased oxidative stress within cells ( In vitro experiments have suggested that even low levels of PINK1 expression can be compensated by increased PRKN expression, leading to induced mitophagy and reduction of cellular ROS stress during CS exposure, a major risk factor for COPD (Mizumura et al