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doi:10.1016/0005-2728(75)90124-3

Orexins, a family of hypothalamic hormones which also enhance feeding, were found to increase following nicotine exposure, in rodents [56]

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When she wanted to shy away from it, people encouraged her to use it, per her memoir, "One More Time." Burnett did the yell as early as 1962 on the "Jack Benny Show." When she got her own show on CBS, "The Carol Burnett Show," she was often asked to do it in the introduction when speaking with the audience