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This gap exists primarily because of the dramatic bioavailability difference

2.3 Neuroinflammation Some studies have shown that berberine activates macrophages and increases their phagocytic function, increases the production of interleukin (IL)-1, and enhances non-specific immunity, can be used as a neuroprotective agent to prevent Alzheimers disease (Panahi et al., 2013)

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Product Facts Supplement Facts Serving Size 2 Softgels Servings Per Container 30 Daily Value not established

Independently of these peripheral actions, GLP-1RAs show direct cerebral effects in animal stroke models, such as reduction of infarct volume, apoptosis, oxidative stress, neuroinflammation, excitotoxicity, bloodbrain barrier permeability, and increased neurogenesis, neuroplasticity, angiogenesis, and brain perfusion