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The Ala370Ser variant of the Rho GTPase Activating Protein 9 (ARHGAP9) gene is another interesting variant implicated in VSA, which in mouse models causes increased vascular infiltration of hematopoietic cells (inflammation) and endothelial dysfunction [56], suggesting that perturbation of the extravascular compartment can also contribute to VSA

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The agency says the new campaign is its first targeting the negative effects of chewing tobacco, including gum disease and multiple forms of cancer.