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The study products included: Product A: Classic Tobacco flavored e-cigarette (2.4 % nicotine, ~75 % glycerin) Product B: Classic Tobacco flavored e-cigarette (2.4 % nicotine, ~50 % glycerin/~20 % propylene glycol) Product C: Menthol flavored e-cigarette (2.4 % nicotine, ~75 % glycerin) Product D: Classic Tobacco flavored e-cigarette (1.6 % nicotine, ~75 % glycerin) Product E: Classic Tobacco flavored e-cigarette (1.6 % nicotine, ~50 % glycerin/~20 % propylene glycol) Product F: Tobacco Cigarette Study design This was a randomized, partially single-blinded, six-period crossover study conducted at a single independent research center (Celerion, Lincoln, NE)

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