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At low doses nicotine causes stimulatory effects on these receptors, however, higher doses or more sustained exposures can cause inhibitory effects leading to neuromuscular blockade

A merit of the NO systems is, because of the small chamber volume, there is less material waste and there is avoidance of exposure via routes other than inhalation

Typically, people using NRTs lower their dose of nicotine in stages until theyve quit completely

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Given the other concerns, not addressed by this study about the toxicity of long-term inhalation of nicotine and the flavourings contained in these products, it seems that the precautionary approach adopted by public health authorities in many countries remains justified.