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64 FDA can deny a PMTA application for various reasons

Although lower doses could lead to fewer digestive problems caused by nicotine, this drug is still addictive and poses certain risks, too

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Other potential symptoms of oral cancer include [2]: White patch (called leucoplakia) or red patch (called erythroplakia) on the inside of the mouth Non-healing scab on the lip or mouth ulcer Bleeding from the mouth that is unrelated to an injury Pain and/or difficulty chewing Swollen glands (lymph nodes) or a mass in the neck Jaw pain or swelling Difficulty swallowing, chewing, speaking, or moving the tongue or jaw Numb tongue or area of the mouth Loose teeth or dentures Persistent bad breath Figure 5: Oral Growth

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