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Sufficient immune response is gained after a period of one to six months with frequent booster injections in order to achieve efficient antibody levels.Citation 29 The individual variable serum antibody concentration partly depends on some genetic factors that control HLA, cytokine and the T cell surface receptor expression, and it is unclear whether individuals who have a poor response to one vaccine have responded poorly to another vaccine.Citation 45 However, serum antibody concentrations may not be the crucial factor for efficacy of the therapy, as was shown in vaccinated rats which had reduced nicotine distribution to the brain even when the doses of nicotine where twice the estimated binding antibodys capacity

I t can also cause an increase in blood pressure and heart rate

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