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Microglial activation phenotypes are described as (1) classic activation (M1 phenotype), (2) alternative activation (M2a phenotype), (3) alternative type II activation (M2b phenotype), and (4) acquired deactivation (M2c phenotype) (113, 114)

Both types require professional treatment for effective removal, but tar stains on teeth tend to respond more readily to scaling and polishing, while nicotine stains on teeth penetrating the enamel require whitening agents to oxidize and break down the embedded pigment

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