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Studies have revealed that the deubiquitinating enzyme ubiquitin specific peptidase 30 (USP30) negatively regulates mitophagy by mediating PRKN deubiquitination ( Mitophagy can occur through both the PINK1/PRKN-dependent pathway and alternative, PINK1/PRKN-independent pathways

Similarly, blood pressure changes have been repeatedly identified as elevated after the use of combustible tobacco products, with acute alterations being observed even after exposure to low amounts of nicotine [78]

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