which physiologic effect of ongoing tobacco smoking leads to copd and COPD: presenting the World Health Organization (WHO) Tobacco Knowledge Summary | Respiratory Research group_4_presentation_2_-_chronic_obstructive_pulmonary_disease_copd - Wiki

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Etiology: Understanding What Causes Gout Gout develops when monosodium urate crystals form in your joints after serum uric acid exceeds its solubility threshold, about 6.8 mg/dL, and if you ask, What causes gout? the short answer is sustained hyperuricemia driving crystal deposition. Uric acid levels rise because you either produce too much purine breakdown or your kidneys fail to excrete enough, with renal underexcretion accounting for roughly 90% of cases

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It may be one of the reasons for increases heart disease in long time smokers

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