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The five discontinued brands were identified as RJRs slowest-selling brands
[DOI] [PMC free article] [PubMed] [Google Scholar] 47.Freedman DM, Wu J, Chen H, Kuncl RW, Enewold LR, Engels EA, Freedman ND, Pfeiffer RM
D was smoking 2 packs of cigarettes a day (40 cigarettes) with an clozapine dosage 700 mg/d as an outpatient, he likely experienced significant induction of clozapine metabolism through CYP1A2, which was no longer present when he stopped smoking
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