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Mutations in key proteins, including -Syn, LRRK2, protein DJ-1 (DJ-1), F-box protein 7 (Fbxo7), and vacuolar protein sorting 35 (VPS35), have been shown to further affect PD pathogenesis through pathways related to Parkin-mediated mitophagy [89]

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However, during embryonic development, ROS are produced locally, acting as primary messengers that affect specific signaling pathways (Hansen, 2006

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Patients with Crohns disease who continue to smoke are at increased risk of more disease flares, worse disease activity and more frequent need for surgery