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Combined, these insults result in tobacco users developing chronic inflammation which leads to destruction of necessary tissue architecture by overactivation of local macrophages and ultimately peribronchiolar fibrosis (55,56)

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Our Oklahoma Tobacco Helpline[JB2] [VT3] offers free coaching and support 24-hours a day, 7 days-a-week, to any Oklahoman that wants to quit tobacco. [pagebreak] 4