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This is also when the first nicotine cravings typically hit
Therefore, we assessed nicotine delivery, puffing behavior, hemodynamic and subjective effects
Given the ease of obtaining buccal mucosal cells for study, there is a robust literature base evaluating the cell-level morphometric changes in oral lesions responding to chronic tobacco use, such as a decreased nuclear/cytoplasmic ratio, which can be an early indicator of malignant transformation (67)
But "natural" doesn't automatically mean safe
You must also want to quit smoking for yourself, not to please your friends or family
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