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Study after study after study has confirmed what the National Academies of Sciences, Engineering, and Medicine concluded in a massive report on the public health consequences of vaping: Substituting e-cigarettes for combustible tobacco cigarettes reduces users exposure to numerous toxicants and carcinogens present in combustible tobacco cigarettes. A significant body of evidence showing vaping is less harmful than smoking has not deterred those in the anti-nicotine space from their campaign against vaping

Experimental evidence in mouse models demonstrates that mtDNA mutations at functionally significant sites, when present at high heteroplasmic levels, lead to defects in oxidative phosphorylation (OXPHOS)

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