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The domains were informed by tobacco control regulations and included sale of products including age-of-purchase, advertising/ promotion/sponsorship, distribution, importation, manufacturing, use including vape-free public places, product design including e-liquid ingredients such as flavours and nicotine, taxation, health warning labels (HWLs)

107 In animal studies, even secondhand smoke exposure had numerous negative effects on bones, including decreasing bone mineral content and density, inhibiting new bone formation while increasing bone resorption, decreasing the thickness of the hard outer layer (cortex) of the bone, and producing weaker, more easily fractured bones