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Pretreatment with low doses of prazosin (0.0625 and 0.125 mg/kg) dose-dependently prevented the elevations in brain reward thresholds associated with precipitated nicotine withdrawal

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[46] : 8283 Even brief advice from physicians may have "a small effect on cessation rates", [129] and there is evidence that the physicians' probability of giving smoking cessation advice declines with the person who smokes age