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There is a great need for large and long-term clinical trials to determine whether different pharmacological agents, including products other than nicotine replacements, can lead to prolonged and significant reductions in smoking and less harm to individuals

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Although toxin levels and biologic effects are generally lower than those of tobacco smoke. As a result, they argued that the potential effectiveness of e-cigarettes in helping smokers quit must be balanced against known and potential safety concerns and that the trials findings must be considered in the context of FDA-approved medications for smoking cessation that have acceptable safety profiles. They recommended that e-cigarettes be used only when FDA-approved treatments (combined with behavioral counseling) fail, that patients be advised to use the lowest dose [of nicotine] needed to manage their cravings, and that there be a clear timeline and off ramp for use. They also recommended that health care providers monitor their patients use of e-cigarettes, like other pharmacologic smoking-cessation treatments. Potential Implications for Youth Adult use of e-cigarettes has potential implications for younger populations, Drs