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The inhibitory inputs and the desensitization of nicotine receptors on the dopamine neurons themselves both contribute to decreased dopamine signaling in the reward pathway, then decreased feelings of pleasure and, therefore, behavioral aversion, Liu said

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Entering this market requires navigating fragmented retail structures and diverse excise policies

We describe our formal search of the literature in the search strategy section of our paper

But this ban does not cover the internet, where up to half of the total quantity of e-cigarettes sold are purchased, the authors point out