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10.1146/annurev.neuro.25.112701.142754 103

Online surveys assessed past 30-day use of conventional cigarettes, JUUL vapor products, and other e-cigarettes/vapor products at 3 and 6 months after their first JUUL purchase

With regard to the molecular toxic mechanisms of tobacco, oxidative stress or inflammasome activation as well as a chronic activation of aryl hydrocarbon receptor signaling can contribute to premature aging and the development of neoplasms by affecting metabolism, extracellular matrix remodeling, inflammation, pigmentation, DNA repair, and apoptosis 10