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In addition, sperm mitochondrial function is critical for fertilization, and loss of sperm function is closely related to changes in mitochondrial integrity, including defects in mitochondrial ultrastructure, mitochondrial genome, and transcriptome, as well as low mitochondrial membrane potential or increased ROS [25, 26]

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Combination approaches can be appropriate for some people when guided by a clinician

E-cigarettes are unsafe despite having fewer hazardous compounds in their aerosol (vapour) than traditional cigarettes