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Conversely, Staudt et al., in a trial with healthy non-smoking subjects exposed to both nicotine-containing and nicotine-free e-cigarettes, noted genetic changes in small airway epithelial cells, alveolar macrophages, and lower airway mononuclear phagocytes after short exposure to EC aerosols

Since everyone develops different habitual smoking patterns, considering different methods and maybe a trial and error approach may be beneficial

i.e., those that cause vasoconstriction of the nasal microcirculation

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