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1 Introduction Cigarette smoking has a negative effect on health, resulting in massive health-related economic losses that include substantial morbidity and mortality ( Nicotine dependence can be defined as a pattern of psychological attributes that result in the compulsive and repetitive search for, and use of, nicotine ( Astrocytes are glial cells that regulate the cellular absorption and release of glutamate, e.g., glutamate homeostasis, thereby affecting the development of drug dependence ( xCT is an antiporter, reliant on L-cysteine, that also contributes to glutamate homeostasis

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