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Symptoms of lung cancer include shortness of breath, persistent cough, chest pain and hoarseness or wheezing

The dose-response relationship between smoking and cardiovascular mortality is non-linear, suggesting that reduction in HPHC concentrations in e-cigarette aerosols may not result in proportional harm reduction and decreased HPHC exposure may be offset by increased use by individuals who believe that e-cigarettes are safer than conventional cigarettes

According to Giovino, the per-capita consumption of tobacco products in the early 1880s was approximately 6 pounds of tobacco per person aged 18 and older

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