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I think it's a kind of simple scent, and the tobacco (I think...?) has a bitterness, perhaps in combination with the plum, that I'm not crazy about (though I often love bitter scents, but those are usually greener or chypres or something...)

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IHFS offers a training focused on the American Indian/Alaska Native health impact of commercial tobacco use

In fruit flies, starvation can induce a reduced nocifensive state through changes to their leucokinin signaling regulation (the way insects use the chemical messenger leucokinin to control important body functions)