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The authors included consideration of coagulation, phase transition, conductive heat and diffusive/convective vapor transport, as well as dilution/mixing into a single-path representation of the stochastic lung dosimetry model IDEAL (inhalation, deposition, and exhalation of aerosols in the lungs) to compute particulate-phase deposition as well as vapor-phase deposition in the airway generations of the human lung

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As smoking became more widespread, retailers needed a bulk format that was: Easy to store Easy to count Easy to sell Over time, cartons became the default bulk unit , while governments began tying taxation, regulation, and reporting to standardized carton volumes, especially once health warnings and excise stamps became mandatory

"The Global Smoking Epidemic: A History and Status Report"