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A recent study has demonstrated that ever-smokers (current and former) have an upregulated pulmonary angiotensin-converting-enzyme-2 (ACE2) gene expression, thus leading to an increased risk for viral binding and entry of both SARS-CoV and SARS-CoV-2 in their lungs [10]

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At this point, most of the active ingredients will have been absorbed, and the pouch will likely be less full and less potent