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for women in the first year after quitting

It accounted for approximately 77% of its free cash flow in 2025

In 2007, its production and sales exceeded 700,000 cases, and in 2008, its sales reached one million cases, making it one of the industry's mega-brands with sales over one million cases

However, it contains roughly the same amount of nicotine per puff as traditional cigarettes around 1.08 mg

Funding This work was supported by the Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan (18590815 and 21590898) and a Grant in Aid of Japanese Arteriosclerosis Prevention Fund