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[50] These derivatives can cause depurination, the removal of bases from the phosphodiester backbone of DNA, followed by inaccurate repair or replication of the apurinic site leading to mutation and eventually cancer

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It contains many harmful chemicals that are known to be the main cause of smoking-related diseases, such as lung cancer

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This is a public health concern given evidence that larger pack sizes are linked to increased smoking, and could undermine existing tobacco control success