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"Because the combustible cigarette smoke and e-cigarette aerosol that people inhale doesn't have direct contact with the blood vessels, and the blood does, we took blood serum (the clear liquid in the blood that remains after it clots) from every participant and put it in contact with endothelial cells in a culture dish to evaluate how the different serum samples affected the functional behavior of those cells," Springer said

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The agency expects many of these products to remain available for purchase by consumers at retail establishments while the FDA works with the manufacturers to ensure the products are in compliance with the requirements of the law