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The difference between the total number of electronic nicotine delivery system applications made (26.64 million) and the various ways in which applications are resolved (refuse to accept, refuse to file, marketing denial order, marketing granted order, withdrawal by applicant, and closure) stood at 497,000 applications unaccounted for in March 2025

Edderkaoui M, Xu S, Chheda C, et al

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Similarly, serum cotinine was linked with an increased risk of nephrolithiasis both as a continuous variable (log 2 -transformed) and as a categorical variable