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Available Newport-branded non-menthol cigarettes were purchased in California in 2025, extracted and tested for sensory cooling activity by Ca 2+ microfluorimetry of HEK293T cells expressing the human TRPM8 cold/menthol receptor

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The report only hints at the likely immediate effect of raising the legal age for tobacco purchases: an outbreak of political wrangling and opposition to a policy that would affect small businesses and drive tobacco use further into the shadows for young smokers

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