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While the number of smokers has markedly decreased over the past decade, major declines have mostly stagnated in the last four years

[14] [10] The discovery that hemoglobin is affected by CO emerged with an investigation by James Watt and Thomas Beddoes into the therapeutic potential of hydrocarbonate in 1793, and later confirmed by Claude Bernard between 1846 and 1857

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Chronic use is defined more by the sustained, ongoing pattern than by a single fixed threshold, and it often signals tolerance, dependence, or difficulty stopping