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Studies conducted as early as the 1940s linked higher risks of lung cancer and heart disease with smoking cigarettes

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25g tobacco pouch: Makes approximately 40-50 cigarettes 50g tobacco pouch: Makes approximately 80-100 cigarettes 30g = standard pack equivalent: Makes approximately 50 cigarettes

Pletcher had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis

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