What we see in clinic The conversation patients bring to us has shifted noticeably over the last few weeks
Receptor Binding Comparison GIP receptor: EC50 ~0.02 nM (comparable to native GIP) GLP-1 receptor: EC50 ~0.1 nM (biased agonist favors Gs/cAMP over -arrestin) Half-life: ~5 days (116 hours), enabled by C20 fatty diacid albumin binding Native GIP half-life: ~57 minutes (rapid DPP-IV cleavage) Native GLP-1 half-life: ~2 minutes (rapid DPP-IV cleavage) Chemical Comparison: Tirzepatide vs Semaglutide vs Retatrutide The following table compares chemical properties only
Example dosage schedule Starting dose: 0.2 0.3 mg weekly for first 4-5 weeks Titration phase: 0.4 0.6 mg weekly for 4-5 weeks and then, if tolerated, 0.9 1.1 mg weekly for 4-5 weeks Maintenance dose for long-term weight management: 1.6 1.9 mg weekly for 4-5 weeks and then, if tolerated, 2.5 mg weekly (maximum dose) The dosage may vary depending on the individual needs, your initial BMI, and glycemic control
GLP-1 Users: High-potency multivitamin with minerals Over-the-counter multivitamins may not provide sufficient nutrients like vitamin D, iron, and vitamin B12, which are critical for muscle and metabolic health
Dermoscopic findings of LHS mainly include regular reticular, granular, linear, curvilinear, arc streaks, fish scale-like, parallel furrow, or parallel ridge patterns in mucocutaneous pigmentary lesions[7-10]
