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COPD is a chronic disease characterized by chronic airway inflammation, airway remodelling, airflow obstruction, and loss of the alveolar parenchyma
These drugs, originally developed for diabetes and now widely used for weight loss, also show promise for other conditions like cardiovascular disease
We now demonstrate that GIPR agonist administration critically relies on Gipr expression in the hindbrain, while GIPR antagonism relies on hypothalamic Gipr expressionboth are probably neuronal populations, given that we used hSyn-driven Cre-expression for the region-specific knockout studies
For the subgroup analysis of the time to the first occurrence of the main 5-component composite endpoint, the pre-specified Cox regression model also included an interaction between treatment group and the subgroup of interest, with the interaction P values evaluated using a score test
