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The practical consideration is timing of dosing to support tolerance

When an ammonium pulse was applied to nitrogen starved cells, GS activity decreased significantly (0.66 fold reduction, p = 0.00, Table 2) within 1 hr of exposure to nitrogen excess

Pharmaceutical companies are now working on generic versions of Victoza and Saxenda after their patents expired, including the worlds largest generic drugmaker, Teva Pharmaceutical Industries which recently launched a generic version of Victoza in the US