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It is important to note that patients with a history of major depression were actually excluded from the phase 3 randomized controlled trials (RCTs) of these medications 1015,2123

In vitro , in comparison with control, healthy animals, the assessment of splenic cells (day 21) demonstrated that the 6-methylprednisolone animals had declined reactivity to nitrogen, while the addition of BPC 157 (1 g/g cream) returned cell reactivity to normal values (Mikus et al., 2001