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A 50% toxicity rate was reached at 0.94mmol/l in HepG2 and 0.68mmol/l in HepG2 ATP7B-KO cells

Unless you tell me there are other reasons

But when it becomes inflamed, it can cause some serious discomfort

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Biweekly protocols (2x per week) are sometimes used during the first 46 weeks of aggressive caloric restriction or in patients with confirmed methylation pathway deficiencies, but there is no clinical evidence that more frequent dosing produces proportionally greater fat loss