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Current market leaders include Novo and Eli Lilly LLY, with treatments such as Ozempic, Wegovy, Mounjaro, and Zepbound addressing both diabetes and obesity

Their role in the pathophysiology of type 2 diabetes (T2D) has been well-characterized, and augmentation by incretin-based therapies leads to improved glycemic control 6

Flux through the glycolytic pathway is tightly controlled through regulation of glycolytic enzyme activity by allosteric modulation, post-translational modifications as well as transcriptional control

During this period, there are no specified limits on the volume of clear fluids that can be consumed

Alcohol compounds this, raising the risk of kidney-related complications