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As compared to placebo, all doses of tirzepatide and semaglutide increased risk for gastrointestinal adverse events, with tirzepatide 15mg yielding the highest increased risk (3.6 times) for nausea, vomiting (4.4 times) and diarrhoea (double the risk)

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Researchers analyzed 79 websites promoting compounded GLP-1 receptor agonists, such as semaglutide and tirzepatide, and uncovered critical transparency issues: Over half did not disclose that their products were not FDA-approved