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In pediatric patients with genetic obesity, such as those carrying the PNPLA3 p.I148 M variant, bariatric surgery may yield greater liver fat reduction, as observed in a study showing more substantial improvements in liver fat content among PNPLA3-associated steatohepatitis patients compared to non-carriers [207]

Surgical Management First : For patients with symptomatic gallstones who are appropriate surgical candidates, laparoscopic cholecystectomy followed by weight loss therapy represents a logical sequence

These medications combine the effects of a GLP-1 receptor agonist with an agonist for GIP, another hormone produced by the small intestine

If the monthly arm comes in materially lower, prescribers will treat monthly as a convenience option for a subset, not the default

doi:10.1042/bj3490455