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Despite this progress, most investigations remain focused on synthesis and chemical characterisation, while biological evaluation remains at a preliminary stage

Inflammatory T cell responses rely on amino acid transporter Asct2 facilitation of glutamine uptake and Mtorc1 kinase activation

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Systemic administration (injectable or oral), which is less common than topical use and not part of approved or standard applications, would theoretically carry different safety considerations requiring appropriate clinical evaluation, though limited research on parenteral administration in animals has suggested acceptable safety profiles at moderate doses