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Adv Med Sci 63:6878

There is strong evidence to support that creatine supplementation improves mood and depression, particularly in women

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In a recent systematic review and meta-analysis of 39 observational studies, use of folic acid-containing supplements preconceptionally or during pregnancy was associated with a 42% lower risk of CL/P (95% CI, 0.49-0.70) (64)