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The research on probiotic-GLP-1 connections, while promising at the ingredient level in preclinical studies, has not been validated in large human clinical trials for finished supplement products like this one

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In addition, in recent years, a significant role has been attributed to coronary microvascular dysfunction as one of the pathogenetic factors for HFpEF progression

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For example, in head-to-head trials, patients on the highest dose of Zepbound lost up to 22.5% of their body weight over 72 weeks, while those taking semaglutide GLP-1 (Wegovy) lost about 15% over a similar period