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54,59 In general, due to the benign nature of NAC therapy, if there is any doubt about the concentration of serum APAP or the timing of ingestion, treatment with NAC is safe and indicated

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A significant change in pH affects the structure of all macromolecules, for instance, presence of a higher proportion of H + or low pH solution cleaves DNA double helix strands by protonating the DNA phosphodiester groups and consequently destabilizing the hydrogen bonds linking DNA nitrogenous bases guanine and cytosine (G-C) ( E

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Available online: [DOI] [PMC free article] [PubMed] [Google Scholar] 20.Negro L., Almeida P., Alcino S., Duro H., Librio T., Melo Silva U., Figueira R., Gonalves S., Neto Parra L