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Science 359 (6374), eaan2788

However, the recent FDA approvals of Wegovy (2021) and Zebound (2023) for weight loss have been met with a tremendous increase in demand for these drugs

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Compared with JAK and TYK2 inhibitors, which exert potent downstream modulation, compounds such as baicalin and EGCG exhibit only partial JAK/STAT or PDE-like immunomodulatory activity, and crucially, they lack human-grade PK/PD validation [36, 37]

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