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This amphipathic nature is crucial for their interaction with lipids

With respect to the primary endpoint of A1C reduction from baseline, dulaglutide 4.5 mg was superior to the 1.5 mg dose at Week 36 under the treatment regimen estimand (mean change from baseline [mean baseline 8.6%]: dulaglutide 1.5 mg -1.54%, dulaglutide 4.5 mg -1.77%

Challenge GLP-1 studies often require extensive participant screening, detailed medical histories, and close coordination across multiple stakeholdersfrom PI oversight to operational, regulatory, and recruitment support

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doi: 10.1111/j.1742-1241.2012.02903.x